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HELP US DEFEAT MSA NOW

Defeat MSA Alliance is a US based 501(c)(3) charity that aspires to balance efforts to support patients, educate medical professionals, raise public awareness and nurture promising research.

GET YOUR FREE TICKETS FOR TWO STREAMING FILMS:

 THROUGHOUT THE MONTH OF OCTOBER – AT YOUR TIME OF CHOICE:

TWO AWARD WINNING AND POWERFUL DOCUMENTARY FILMS:

“A DAY FOR SUSANA”

(Brazil, 2018 with English & Spanish Subtitles, 85 Minutes)

&

“MSA: THE IAN MACINDOE STORY”

(Australia, 2017 with English & Spanish Subtitles, 41 MINUTES)

 

— JUST IN TIME FOR OCT 3, WORLD MSA DAY BUT WATCH ANYTIME IN OCTOBER!

(Please Read The Short Film Summaries and Watch Film Trailers on Film Streaming Pages)

 


MISSED THE MSA CONFERENCE?

NOW WATCH THE VIRTUAL MSA CONFERENCE

 

ON DIAGNOSIS – DR ANTHONY LANG:

ON TREATMENTS – DR EDWIN GEORGE:

SPEECH & SWALLOWING

– J. KILENY & BECCA WALLACE:

ON CLINICAL TRIALS – DR HORACIO KAUFMANN:

ON MSA RESEARCH – DR PATRIK BRUNDIN:

PHYSICAL & OCCUPATIONAL THERAPY

– M. WEAVER & K. VRYHOF:

News from Social Media

Our hearts are with the families that have lost loved ones from MSA in the month of October... On behalf of all the volunteers associated with our six member charity consortium, "MSA United" - we want to express our heartfelt condolences...💜🙏
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If you are considering memorizing someone, please consider any of our giving programs. We continue to fight MSA in the honor of all those we have lost - for we understand, all of the volunteer board members of Defeat MSA united charities have lost members of our family too. #WeRememberMSA #defeatmsa 💜 defeatmsa.org/giving-programs/
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GOT A JUNKER IN YOUR DRIVEWAY?

We’ve partnered with CAR EASY to allow donors to donate their car to with proceeds going to the MSA cause. HELP DEFEAT MSA BY DONATING YOUR CAR IN ANY CONDITION!
CLICK HERE: careasy.org/nonprofit/defeat-msa-alliance
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BREAKING NEWS -RE: ALTERITY MSA STUDY

MELBOURNE, AUSTRALIA AND SAN FRANCISCO, USA – 27th October 2020: Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) (“Alterity” or “the Company”) today announced it has commenced enrolling patients with Multiple System Atrophy (MSA) in its bioMUSE Study in the United States.

BioMUSE is a natural history study that aims to track the progression of patients with MSA, a Parkinsonian disorder without approved therapy. The study is being conducted in collaboration with Vanderbilt University Medical Center in the US under the direction of Daniel Claassen, MD, Associate Professor of Neurology and Principal Investigator. Natural history studies are important for characterizing disease progression in selected patient populations. The study will provide vital information on early stage MSA patients to optimize the design of Alterity’s Phase 2 study in MSA. The study will also inform the selection of biomarkers suitable to evaluate target engagement and preliminary efficacy.

Alterity’s lead compound ATH434 has already successfully completed Phase 1 clinical trial and is advancing toward a Phase 2 clinical trial.

Dr. Claassen said: “This is an important study to expand our understanding of MSA. We are enrolling early stage patients who stand to gain the most from disease modifying treatments. I look forward to working with Alterity on this project and I hope it can provide the foundation for advancing treatments such as ATH434 into the clinic.”

MSA is a neurodegenerative disease with major sources of disability resulting from motor symptoms characteristic of Parkinson’s disease and impaired ability to maintain normal blood pressure, bowel function and bladder control. Current treatment includes medications and lifestyle changes to help manage symptoms, but there is no treatment of the underlying cause and no cure.

The study is enrolling early stage MSA patients and will track changes in clinical measures and biomarkers for up to one year. Over the course of the study, patients will undergo comprehensive evaluation with detailed neurological examination and clinical rating scales of motor, autonomic and activities-of-daily-living symptoms along with specialized neuroimaging and assessment of protein biomarkers in diverse biological specimens.

Data from bioMUSE will also be used to inform patient selection in Alterity’s upcoming Phase 2 clinical trial of ATH434, its lead clinical candidate for the treatment of MSA. The US FDA has encouraged Alterity to utilize data from the bioMUSE study to aid in the development of efficacy endpoints for the Phase 2 study.

Vanderbilt University Medical Centre is one of the largest academic medical centres in the southeast US managing more than 2 million patients each year. The School of Medicine’s biomedical research program is among the nation’s top 10 in terms of National Institutes of Health peer review funding.

Dr David Stamler, Chief Medical Officer, added: “As we prepare for our Phase 2 study, the data from bioMUSE will provide key information to help us optimize the study design. Starting this study brings us one step closer to finding novel treatments for this devastating condition.”

Interested in the Biomuse Study?

Contact: MSAresearch@defeatmsa.org
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***NEW: FULL MSA Virtual Conference 2020 ***
https://www.youtube.com/playlist?list=PLKYOyVv6SuAGO6-_smwnRUZBc8cOqxlL- via @msadownunder @Canada_MSA_AMS @InMemoriamMSA @MSAtrust @CureMSA @ClinAutonRes @VAInstitute @JoelWattsLab @BrundinPatrik @peelaerts_w

LOOKING FOR OTHER WAYS TO GET INVOLVED?

LOOKING FOR OTHER WAYS TO GET INVOLVED?

MSA Expert
Spotlight

Wouter Peelaerts, PhD

Wouter Peelaerts, PhD

Dr. Wouter Peelaerts is an experienced neuroscientist with special expertise in degenerative brain diseases. He earned his Ph.D. in biomedical sciences from KU Leuven and subsequently completed a postdoctoral fellowship there focused on neurobiology and gene therapy under the mentorship of Prof. Veerle Baekelandt. His efforts helped uncover new insights that further link the abnormal protein alpha-synuclein to neurodegenerative diseases, in particular Parkinson’s and Multiple System Atrophy. He has received numerous accolades for his research, including the 2020 JiePie award for MSA research, a prestigious 2017–2019 Fulbright Fellowship and the ATCG and ID&T postdoctoral award. In 2017, he joined the lab of Dr. Patrik Brundin at Van Andel Institute, MI, USA. His current research focuses on drug repurposing and how infections can trigger Multiple System Atrophy. Dr. Peelaerts serves on the Scientific and Medical Research Advisory Committee for the six charities that make up MSA United International Consortium, which includes Defeat MSA Alliance (USA). He is Chair of the Alliance’s Scientific Research Section.

List of Publications

Christopher T. Tulisiak, Mercado G, Peelaerts W, Brundin L, Brundin P. 2019. Chapter Seventeen – Can infections trigger alpha-synucleinopathies? Progress in molecular biology and translational science. Vol 168. Pages 299-322.

Quansah E*, Peelaerts W*, Langston JW, Simon DK, Colca J, Brundin P. 2018. Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration. Mol Neurodegener 13:28.
*Contributed equally

Peelaerts W, Outeiro TF. 2017. Synuclein misfolding as a therapeutic target. Disease-modifying therapies and targets in neurodegenerative disorders. Academic Press.

Peelaerts W, Baekelandt V. 2016. ɑ-Synuclein strains and the variable pathologies of synucleinopathies. J Neurochem 139(Suppl 1):256–274.

 

Spotlight Links

“Sticking With MSA” -Dr. Wouter Peelearts (Defeat MSA Alliance Blog Launch, April 2019)

Fulbright grantee (2017–2018)

Integrated DNA Technologies and Advanced Technologies and Community Giving Foundation award (2017)

FWO postdoctoral fellowship (2017 – 2020)

Annual Award for Movement Disorders, best scientific article published by a young investigator (2015)

 

about the

Defeat MSA Awareness Shoe – #KickMSA

The Defeat MSA Awareness Shoe ™ has traveled to multiple countries, rubbed shoulders with some notable people and visited many famous landmarks. The Shoe is a tool for spreading MSA awareness, increasing support for MSA patients and their caregivers and fighting MSA by raising vital research dollars. It’s journey is undertaken in memory of all those that have died due to MSA and in support of all those presently fighting Multiple System Atrophy!

Learn more about the story and the globetrotting journey of the MSA Awareness Shoe here or via www.MSAshoe.org

#DefeatMSA #KickMSA #DeFeetMSA

ABOUT

The Defeat MSA Awareness Shoe – #KickMSA

The Defeat MSA Awareness Shoe ™ has traveled to dozens of countries, rubbed shoulders with some notable people and visited many famous landmarks. The Shoe is a tool for spreading MSA awareness, increasing support for MSA patients and their caregivers and fighting MSA by raising vital research dollars. It’s journey is undertaken in memory of all those that have died due to MSA and in support of all those presently fighting Multiple System Atrophy!

To date, the Shoe has “Kicked MSA” in multiple countries across the world.

Learn more about the story and the globetrotting journey of the MSA Awareness Shoe here or via www.MSAshoe.org

#DefeatMSA #KickMSA #DeFeetMSA

Join the world-wide MSA Awareness initiative

Join the world-wide MSA Awareness initiative

PATIENTS NEED OUR HELP

Defeat MSA Alliance invites all our friends and allies, around the world, to join us in this noble fight, to speak for those who cannot, with one mind, one heart and one voice: to defeat MSA forever!

Join the world-wide MSA Awareness initiative

OUR LEGACY GRANTS

OUR

LEGACY

GRANTS

The Defeat MSA special Individual Named Legacy Grants program enables donors to fund a scientific research, medical education, patient support or public awareness grant and name it in their own name, in tribute to someone or in memory of a loved one. The Legacy Grants program designates four levels of grants: $15,000 (Platinum), $10,000 (Gold), $5,000 (Silver) and $2,500 (Bronze). MSA research grants begin at the $10,000 level. Please email us: legacyfunds@defeatmsa.org, if you are interested in finding out more about this lasting gift.

MSA BLOGS 

Caregiver’s Blog

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Researcher’s Blog

“Sticking With MSA” -Dr. Wouter Peelearts (Researcher, Michigan)

“Sticking With MSA” -Dr. Wouter Peelearts (Researcher, Michigan)

Sticking with Multiple System Atrophy

Multiple System Atrophy (MSA) is a rare brain disorder that until recently was largely ignored by the research community. MSA is a rapidly progressing neurodegenerative disease caused by a decline of the body’s most basic and vital functions including breathing, digestion, urination, controlling blood pressure and movement.

Advocate’s Blog

“Defeat MSA Announces Global Research Consortium” (07-16-20)

“Defeat MSA Announces Global Research Consortium” (07-16-20)

FOR IMMEDIATE RELEASE “Defeat MSA Announces Global Research Consortium”  (07/16/2020) DETROIT, MI—Defeat MSA Alliance announces the formation of a new global consortium of charities for people living with Multiple System Atrophy. The consortium, officially named...

THANK YOU TO ALL OUR RECENT VOLUNTEERS!

THANK YOU TO ALL OUR RECENT VOLUNTEERS!

A BIG BIG THANK YOU TO ALL OUR RECENT VOLUNTEERS! Together, We Can and Will Defeat MSA Forever!! SERGEY POVALIAEV SANDRA BETTENHAUSEN JENNIFER KILENY BECCA WEISS MARY BETH MCCORD FLYNN MICHAEL SMITH DUSTIN AND CARLA RIOS DAMIEN GAFFNEY VINCE NEIL AND RAIN HANNAH MIKE...

New Charity and New Partnership Moves Forward – Down Under!

New Charity and New Partnership Moves Forward – Down Under!

DEFEAT MULTIPLE SYSTEM ATROPHY AUSTRALIA AND NEW ZEALAND, Ltd., a newly formed nonprofit, the first of its kind in Australia and New Zealand has forged a  partnership with Defeat MSA Alliance. Already a global leader in the fight against Multiple System Atrophy, the...

Patient’s Blog

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“Defeat MSA Alliance is an amazing organization, giving voice to those affected by this little known, devastating disease. I have watched this grass roots effort grow since the beginning as a work of love and devotion by its founders. Indescribable grief and suffering has been channeled into positive action to help fund promising research and provide support for others dealing with MSA. It is an important and worthwhile organization and I hope to see it continue to serve more and more people in need.”

Elena Fracassa, MS

“I have observed this charity grow since it’s inception. The charity remains true to its objective of sponsoring clinical research, supporting patients and families living with this dreadful disease, through support groups, loaner equipment through the loaner closet program and networking on social media to connect families sharing their experiences across the world. This disease does not have a marathon or a 5k run in its name; so the charity also uses an intriguing device: a traveling shoe as a symbolic marathon to spread awareness among lay public about this devastating disease. “

Dr. Pratik Bhattacharya, MD, MPH

LOOKING FOR OTHER WAYS TO GET INVOLVED?

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