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Pain is an often-overlooked aspect of MSA, but it is very common. Studies have found that pain is reported anywhere from 50% to 80% in patients with MSA. Pain tended to be more common among MSA-P, as compared to MSA-C subtype.

1. Non-pharmacologic treatment for pain include:

  • Exercise and physical therapy are ways to help deal with the pain associated with MSA.

2. Medication for the treatment of pain include:

  • Dopaminergic medication, including levodopa and pramipexole, have shown promise for pain relief.


  1. You HY, Wu L, Yang HT, Yang C, Ding XL. A Comparison of Pain between Parkinson’s Disease and Multiple System Atrophy: A Clinical Cross-Sectional Survey. Pain Res Manag. 2019;2019:3150306.